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April 21, 1921: A cloud over Chicago as White Sox return for home opener after World Series scandal

Sol White (NATIONAL BASEBALL HALL OF FAME LIBRARY)

April 30, 1921: Chicago Giants defeat Columbus Buckeyes in Negro National League debut

Dave Brown (SEAMHEADS.COM)

May 7, 1921: Chicago’s Dave Brown outduels Monarchs’ Rube Curry on Opening Day

May 7, 1921: Detroit Stars and Bacharach Giants hit the long ball

Rogers Hornsby (TRADING CARD DB)

April 12, 1922: Del Gainer and Rogers Hornsby power Cardinals to Opening Day romp over Pirates

Hugh McQuillan

April 17, 1923: Reformer, rogue meet before Giants’ win on Opening Day in Boston

April 18, 1923: Babe Ruth homers in Yankee Stadium’s grand opening, hinting at franchise’s dynastic future

Mule Suttles (Trading Card DB)

April 28, 1924: Birmingham Black Barons make Negro National League debut with win over Cuban Stars

Cum Posey

April 12, 1925: Homestead Grays open season by defeating McConkey Macks

Tris Speaker with the Cleveland Indians (NATIONAL BASEBALL HALL OF FAME LIBRARY)

April 14, 1925: Indians, Browns combine for 35 runs on Opening Day

Johnny Morrison (Trading Card DB)

April 22, 1925: Championship-bound Pirates win home opener with record-setting 7 triples

April 22, 1925: Cardinals inflict death by a thousand singles to win home opener over Reds

Howard Ehmke (TRADING CARD DB)

April 13, 1926: First Red Sox game is broadcast on Boston radio

April 13, 1926: Big Train takes a long journey to defeat Connie Mack’s Athletics

April 12, 1927: Cubs wallop defending champion Cardinals on Opening Day

SABR-Rucker Archive

April 12, 1927: Murderers’ Row Yankees kick off new pennant chase amid overflowing crowds

April 16, 1929: Earl Averill homers in first plate appearance during Indians’ debut

Ad Liska

April 17, 1929: Athletics open season by setting tone for dynasty to come

April 18, 1929: Babe Ruth celebrates ‘honeymoon’ with a home run

April 17, 1934: Cubs’ Lon Warneke makes history with Opening Day one-hitter

Wes Ferrell

April 16, 1935: Wes Ferrell two-hits ‘Ruth-less’ Yankees on Opening Day, wins on Gehrig error

April 16, 1935: The Babe returns to Boston as a Brave

May 18, 1935: Negro League Brooklyn Eagles play inaugural home opener at Ebbets Field

Danny MacFayden (TRADING CARD DB)

April 14, 1936: Boston Bees make their debut on Opening Day

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